Validating Metal‐Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications

DOI Web Site Web Site 被引用文献1件
  • Stefan Wuttke
    Department of Chemistry and Center for NanoScience (CeNS) University of Munich (LMU) 81377 Munich Germany
  • Andreas Zimpel
    Department of Chemistry and Center for NanoScience (CeNS) University of Munich (LMU) 81377 Munich Germany
  • Thomas Bein
    Department of Chemistry and Center for NanoScience (CeNS) University of Munich (LMU) 81377 Munich Germany
  • Simone Braig
    Department of Pharmacy University of Munich (LMU) 81377 Munich Germany
  • Katharina Stoiber
    Department of Pharmacy University of Munich (LMU) 81377 Munich Germany
  • Angelika Vollmar
    Department of Pharmacy University of Munich (LMU) 81377 Munich Germany
  • Dominik Müller
    Institute of Neuroanatomy Hannover Medical School Hannover 30625 Germany
  • Kirsten Haastert‐Talini
    Institute of Neuroanatomy Hannover Medical School Hannover 30625 Germany
  • Jörn Schaeske
    Department of Prosthetic Dentistry and Biomedical Materials Science Hannover Medical School Hannover 30625 Germany
  • Meike Stiesch
    Department of Prosthetic Dentistry and Biomedical Materials Science Hannover Medical School Hannover 30625 Germany
  • Gesa Zahn
    Institute for Inorganic Chemistry Leibniz University Hannover Hannover 30167 Germany
  • Alexander Mohmeyer
    Institute for Inorganic Chemistry Leibniz University Hannover Hannover 30167 Germany
  • Peter Behrens
    Institute for Inorganic Chemistry Leibniz University Hannover Hannover 30167 Germany
  • Oliver Eickelberg
    Comprehensive Pneumology Center (CPC) University Hospital, University of Munich (LMU) Member of the German Center for Lung Research (DZL) 81377 Munich Germany
  • Deniz A. Bölükbas
    Comprehensive Pneumology Center (CPC) University Hospital, University of Munich (LMU) Member of the German Center for Lung Research (DZL) 81377 Munich Germany
  • Silke Meiners
    Comprehensive Pneumology Center (CPC) University Hospital, University of Munich (LMU) Member of the German Center for Lung Research (DZL) 81377 Munich Germany

書誌事項

公開日
2016-11-15
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/adhm.201600818
公開者
Wiley

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説明

<jats:p>Metal‐organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood‐mediated and local lung‐specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively.</jats:p>

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