Pharmacokinetics of danofloxacin after single oral and intravenous administration in non‐laying hens

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  • Jun‐Cheng Chen
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Ji‐Jun Kang
    National Feed Drug Reference Laboratories, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing China
  • Mei Zhang
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Hao‐Tian Shao
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Zhe‐Wen Song
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Kai‐Li Ma
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Fang Yang
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China
  • Fan Yang
    College of Animal Science and Technology Henan University of Science and Technology Luoyang China

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<jats:title>Abstract</jats:title><jats:p>The current study aimed to explore the pharmacokinetics of danofloxacin in non‐laying hens after a single oral (PO) and intravenous (IV) dose, both at 5 mg/kg body weight (BW). Eighteen 13‐week‐old healthy hens were equally and randomly divided into two groups. After both doses, blood samples (approximately 1 ml) were collected at different time points. Danofloxacin concentrations were quantified by a validated high‐performance liquid chromatography (HPLC) method followed by a non‐compartmental analysis using the software of WinNonLin. The elimination half‐lives (t<jats:sub>1/2λz</jats:sub>s) after PO and IV routes were determined as 8.15 ± 3.37 and 7.69 ± 3.40 h, respectively. After IV administration, danofloxacin had an initial concentration (C<jats:sub>0</jats:sub>) of 3.62 μg/ml, a volume of distribution at steady state (V<jats:sub>SS</jats:sub>) of 3579.72 ± 454.29 ml/kg, and a total body clearance (Cl) of 0.49 ml/h/g. After PO administration, the absolute bioavailability and absorption half‐life (t<jats:sub>1/2ka</jats:sub>) were calculated as 100.99% ± 23.10% and 0.82 ± 0.58 h, respectively. Based on the calculated ratio values of AUC/MIC and C<jats:sub>max</jats:sub>/MIC, an oral dose of 5 mg/kg danofloxacin would be expected to successfully treat hens infected with strains with MIC values ≤0.1 μg/ml.</jats:p>

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