Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats

DOI Web Site 2 Citations
  • Angela M. Bosco-Lauth
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Airn E. Hartwig
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Stephanie M. Porter
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Paul W. Gordy
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Mary Nehring
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Alex D. Byas
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Sue VandeWoude
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Izabela K. Ragan
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Rachel M. Maison
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
  • Richard A. Bowen
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523

Description

<jats:title>Significance</jats:title> <jats:p>SARS-CoV-2 is an emerging pathogen that has already had catastrophic consequences on the health and well-being of people worldwide. As a zoonotic virus, the implications for animal populations are largely unknown. This manuscript describes a pilot study in which domestic cats and dogs were assessed for their susceptibility to infection. While neither species developed clinical disease in this study, cats shed infectious virus for up to 5 d and infected naive cats via direct contact, while dogs do not appear to shed virus. Cats that were reinfected with SARS-CoV-2 mounted an effective immune response and did not become reinfected. These studies have important implications for animal health and suggest that cats may be a good model for vaccine development.</jats:p>

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