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- Éléa Héberlé
- CNRS, University of Strasbourg, UMR7242 Biotechnology and Cell Signaling, Illkirch 67412, France
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- Anaïs Flore Bardet
- CNRS, University of Strasbourg, UMR7242 Biotechnology and Cell Signaling, Illkirch 67412, France
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- Marnie Blewitt
- editor
抄録
<jats:title>Abstract</jats:title> <jats:p>Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential to modulate TF binding to DNA. Although DNA methylation has long been thought to repress TF binding, a more recent model proposes that TF binding can also inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and TF binding affect each other. Further in vivo experiments will be required to generalize these models.</jats:p>
収録刊行物
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- Essays in Biochemistry
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Essays in Biochemistry 63 (6), 727-741, 2019-11-22
Portland Press Ltd.