Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo

DOI Web Site 被引用文献1件
  • Didier Malamba-Lez
    Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo
  • Désire Tshala-Katumbay
    Department of Neurology and School of Public Health, Oregon Health & Science University, Portland, OR 97007, USA
  • Virginie Bito
    Doctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium
  • Jean-Michel Rigo
    Doctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium
  • Richie Kipenge Kyandabike
    Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo
  • Eric Ngoy Yolola
    Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo
  • Philippe Katchunga
    Department of Internal Medicine, Official University of Bukavu, Bukavu 11102, Democratic Republic of the Congo
  • Béatrice Koba-Bora
    Department of Internal Medicine, Service of Neurology, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo
  • Dophra Ngoy-Nkulu
    Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo

書誌事項

公開日
2021-05-06
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.3390/ijerph18094956
公開者
MDPI AG

説明

<jats:p>Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.</jats:p>

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