Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
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- Mary B. Daly
- 1Fox Chase Cancer Center;
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- Tuya Pal
- 2Vanderbilt-Ingram Cancer Center;
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- Michael P. Berry
- 3St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;
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- Saundra S. Buys
- 4Huntsman Cancer Institute at the University of Utah;
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- Patricia Dickson
- 5Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;
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- Susan M. Domchek
- 6Abramson Cancer Center at the University of Pennsylvania;
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- Ahmed Elkhanany
- 7O'Neal Comprehensive Cancer Center at UAB;
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- Susan Friedman
- 8FORCE: Facing Our Risk of Cancer Empowered;
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- Michael Goggins
- 9The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;
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- Beth Y. Karlan
- 11UCLA Jonsson Comprehensive Cancer Center;
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- Seema Khan
- 12Robert H. Lurie Comprehensive Cancer Center of Northwestern University;
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- Catherine Klein
- 13University of Colorado Cancer Center;
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- Allison W. Kurian
- 14Stanford Cancer Institute;
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- Christine Laronga
- 15Moffitt Cancer Center;
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- Jennifer K. Litton
- 16The University of Texas MD Anderson Cancer Center;
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- Carolyn S. Menendez
- 18Duke Cancer Institute;
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- Sofia D. Merajver
- 19University of Michigan Rogel Cancer Center;
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- Barbara S. Norquist
- 20Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;
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- Kenneth Offit
- 21Memorial Sloan Kettering Cancer Center;
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- Holly J. Pederson
- 22Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;
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- Kristen Mahoney Shannon
- 25Massachusetts General Hospital Cancer Center;
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- Rebecca Shatsky
- 26UC San Diego Moores Cancer Center;
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- Kala Visvanathan
- 9The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;
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- Jeffrey N. Weitzel
- 27City of Hope National Medical Center;
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- Myra J. Wick
- 28Mayo Clinic Cancer Center;
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- Kari B. Wisinski
- 29University of Wisconsin Carbone Cancer Center;
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- Matthew B. Yurgelun
- 30Dana-Farber/Brigham and Women’s Cancer Center; and
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- Susan D. Darlow
- 31National Comprehensive Cancer Network
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- Mary A. Dwyer
- 31National Comprehensive Cancer Network
説明
<jats:p>The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased risk of breast, ovarian, and pancreatic cancer and recommended approaches to genetic testing/counseling and management strategies in individuals with these pathogenic or likely pathogenic variants. This manuscript focuses on cancer risk and risk management for BRCA-related breast/ovarian cancer syndrome and Li-Fraumeni syndrome. Carriers of a <jats:italic>BRCA1/2</jats:italic> pathogenic or likely pathogenic variant have an excessive risk for both breast and ovarian cancer that warrants consideration of more intensive screening and preventive strategies. There is also evidence that risks of prostate cancer and pancreatic cancer are elevated in these carriers. Li-Fraumeni syndrome is a highly penetrant cancer syndrome associated with a high lifetime risk for cancer, including soft tissue sarcomas, osteosarcomas, premenopausal breast cancer, colon cancer, gastric cancer, adrenocortical carcinoma, and brain tumors.</jats:p>
収録刊行物
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- Journal of the National Comprehensive Cancer Network
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Journal of the National Comprehensive Cancer Network 19 (1), 77-102, 2021-01-06
Harborside Press, LLC