Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals

Joshua M. Kirsch, Robert S. Brzozowski, Dominick Faith, June L. Round, Patrick R. Secor, Breck A. Duerkop

doi:10.1146/annurev-virology-091919-101238

Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals

DOI Web Site 被引用文献1件

Joshua M. Kirsch

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA;
Robert S. Brzozowski

Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA;
Dominick Faith

Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA;
June L. Round

Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA;
Patrick R. Secor

Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA;
Breck A. Duerkop

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA;

抄録

<jats:p>Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals. These interactions are multifaceted and are influenced by environmental conditions. In this review, we discuss phage-bacteria interactions as they relate to the complex environment of the gut. Within the mammalian and invertebrate guts, phages and bacteria engage in diverse interactions including genetic coexistence through lysogeny, and phages directly modulate microbiota composition and the immune system with consequences that are becoming recognized as potential drivers of health and disease. With greater depth of understanding of phage-bacteria interactions in the gut and the outcomes, future phage therapies become possible.</jats:p>