ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

DOI Web Site 2 Citations
  • Colleen R. Kelly
    Division of Gastroenterology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA;
  • Monika Fischer
    Division of Gastroenterology, Indiana University, Indianapolis, Indiana, USA;
  • Jessica R. Allegretti
    Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;
  • Kerry LaPlante
    Department of Pharmacy Practice, University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA;
  • David B. Stewart
    Department of Surgery, University of Arizona Health Sciences, Tucson, Arizona, USA;
  • Berkeley N. Limketkai
    Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA;
  • Neil H. Stollman
    Division of Gastroenterology, Alta Bates Summit Medical Center, East Bay Center for Digestive Health, Oakland, California, USA.

Description

<jats:p> <jats:italic toggle="yes">Clostridioides difficile</jats:italic> infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with <jats:italic toggle="yes">C. difficile</jats:italic> infection and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations Assessment, Development, and Evaluation but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not the only, approach to clinical scenarios.</jats:p>

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