An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on‐site analysis
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- Eric Deconinck
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Camille Aït‐Kaci
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Andries Raes
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Michaël Canfyn
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Jean‐Luc Bothy
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Céline Duchateau
- Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products Sciensano Brussels Belgium
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- Corenthin Mees
- RD3 Unit of Pharmacognosy, Bioanalysis and Drug Discovery, Faculty of Pharmacy Université Libre de Bruxelles Campus de la Plaine Brussels Belgium
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- Kris De Braekeleer
- RD3 Unit of Pharmacognosy, Bioanalysis and Drug Discovery, Faculty of Pharmacy Université Libre de Bruxelles Campus de la Plaine Brussels Belgium
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- Lies Gremaux
- Scientific Direction Epidemiology and Public Health, Section Lifestyle and Chronic Diseases Sciensano Brussels Belgium
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- Peter Blanckaert
- Scientific Direction Epidemiology and Public Health, Section Lifestyle and Chronic Diseases Sciensano Brussels Belgium
Description
<jats:title>Abstract</jats:title><jats:p>More and more events, such as the summer music festivals, are considering the possibilities for implementing on‐site testing of psychoactive drugs in the context of prevention and harm reduction. Although the on‐site identification is already implemented by plenty of drug checking services, the required rapid quantitative dosing of the composition of illicit substances is still a missing aspect for a successful harm reduction strategy at events. In this paper, an approach is presented to identify white powders as amphetamine, cocaine, ketamine or others and to estimate the purity of the amphetamine, cocaine and ketamine samples using spectroscopic techniques hyphenated with partial least squares (PLS) modelling. For identification purposes, it was observed that mid‐infrared spectroscopy hyphenated with PLS‐discriminant analysis allowed the distinction between amphetamine, cocaine, ketamine and other samples and this with a correct classification rate of 93.1% for an external test set. For quantitative estimation, near‐infrared spectroscopy was more performant and allowed the estimation of the dosage/purity of the amphetamine, cocaine and ketamine samples with an error of more or less 10% w/w. An easily applicable, practical and cost‐effective approach for on‐site characterisation of the majority of the psychoactive samples encountered in Belgian nightlife settings based on IR spectroscopy was proposed.</jats:p>
Journal
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- Drug Testing and Analysis
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Drug Testing and Analysis 13 (3), 679-693, 2020-11-24
Wiley
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Details 詳細情報について
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- CRID
- 1360016870114071808
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- DOI
- 10.1002/dta.2973
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- ISSN
- 19427611
- 19427603
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- Data Source
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- Crossref