Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
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- Berislav V. Zlokovic
- University of Southern California Los Angeles California USA
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- Rebecca F. Gottesman
- Johns Hopkins University Baltimore Maryland USA
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- Kenneth E. Bernstein
- Cedars‐Sinai Medical Center Los Angeles California USA
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- Sudha Seshadri
- University of Texas Health Science Center San Antonio and Boston University San Antonio Texas USA
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- Ann McKee
- VA Boston Healthcare System and Boston University Boston Massachusetts USA
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- Heather Snyder
- Alzheimer's Association Chicago Illinois USA
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- Steven M. Greenberg
- Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA
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- Kristine Yaffe
- University of California, San Francisco San Francisco California USA
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- Chris B. Schaffer
- Cornell University Ithaca New York USA
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- Chun Yuan
- University of Washington Seattle Washington USA
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- Timothy M. Hughes
- Wake Forest School of Medicine Winston‐Salem North Carolina USA
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- Mat J. Daemen
- Amsterdam UMC University of Amsterdam Amsterdam the Netherlands
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- Jeff D. Williamson
- Wake Forest School of Medicine Winston‐Salem North Carolina USA
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- Hector M. González
- University of California San Diego La Jolla California USA
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- Julie Schneider
- Rush University Chicago Illinois USA
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- Cheryl L. Wellington
- University of British Columbia, Vancouver and Kelowna British Columbia
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- Zvonimir S. Katusic
- Mayo Clinic Rochester Minnesota USA
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- Luke Stoeckel
- National Institute on Aging Bethesda Maryland USA
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- James I. Koenig
- National Institute of Neurological Disorders and Stroke Bethesda Maryland USA
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- Roderick A. Corriveau
- National Institute of Neurological Disorders and Stroke Bethesda Maryland USA
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- Lawrence Fine
- National Heart, Lung, and Blood Institute Bethesda Maryland USA
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- Zorina S. Galis
- National Heart, Lung, and Blood Institute Bethesda Maryland USA
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- Jared Reis
- National Heart, Lung, and Blood Institute Bethesda Maryland USA
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- Jacqueline D. Wright
- National Heart, Lung, and Blood Institute Bethesda Maryland USA
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- Jue Chen
- National Heart, Lung, and Blood Institute Bethesda Maryland USA
説明
<jats:title>Abstract</jats:title><jats:p>Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.</jats:p>
収録刊行物
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- Alzheimer's & Dementia
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Alzheimer's & Dementia 16 (12), 1714-1733, 2020-10-08
Wiley