Targeting the Orexin System for Prescription Opioid Use Disorder

DOI Web Site 被引用文献1件
  • Alessandra Matzeu
    Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
  • Rémi Martin-Fardon
    Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA

説明

<jats:p>Prescription opioids are potent analgesics that are used for clinical pain management. However, the nonmedical use of these medications has emerged as a major concern because of dramatic increases in abuse and overdose. Therefore, effective strategies to prevent prescription opioid use disorder are urgently needed. The orexin system has been implicated in the regulation of motivation, arousal, and stress, making this system a promising target for the treatment of substance use disorder. This review discusses recent preclinical studies that suggest that orexin receptor blockade could be beneficial for the treatment of prescription opioid use disorder.</jats:p>

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