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- Soo Seok Hwang
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Jaechul Lim
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Zhibin Yu
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Philip Kong
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Esen Sefik
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Hao Xu
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Christian C. D. Harman
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Lark Kyun Kim
- Severance Biomedical Science Institute and BK21 PLUS Project for Medical Sciences, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Republic of Korea.
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- Gap Ryol Lee
- Department of Life Science, Sogang University, Seoul 04107, Republic of Korea.
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- Hua-Bing Li
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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- Richard A. Flavell
- Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
書誌事項
- 公開日
- 2020-03-13
- DOI
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- 10.1126/science.aax0194
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Deadenylate or activate?</jats:title> <jats:p> When cells are quiescent, they undergo reversible cell cycle arrest and evince low basal metabolism. Naïve T cells are normally quiescent until they recognize cognate antigens through T cell receptor–costimulatory molecule signaling. T cell quiescence appears to be an active process, but the mechanistic details are poorly understood. Hwang <jats:italic>et al.</jats:italic> report that the transcription factors BTG1 and BTG2 are selectively expressed in quiescent T cells. In mice, T cells conditionally knocked out for both factors showed enhanced proliferation and a lowered threshold of activation both in vitro and in response to <jats:italic>Listeria monocytogenes</jats:italic> infection. Deficiency of BTG1 and BTG2 resulted in increases in global messenger RNA half-life, suggesting that messenger RNA deadenylation and degradation are important processes for maintaining T cell quiescence. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6483" page="1255" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax0194">1255</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 367 (6483), 1255-1260, 2020-03-13
American Association for the Advancement of Science (AAAS)