The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease

  • Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Giancarlo Russo
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Alexander Richards
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Valentina Moskvina
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Dobril Ivanov
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Denise Harold
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Rebecca Sims
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Richard Abraham
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Paul Hollingworth
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Jade Chapman
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Marian Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Jaspreet Singh Pahwa
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Kimberley Dowzell
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Amy Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Nicola Jones
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Charlene Thomas
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Alexandra Stretton
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Angharad R. Morgan
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Simon Lovestone
    King's College London, Institute of Psychiatry, Kings College, London, UK
  • John Powell
    Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK
  • Petroula Proitsi
    Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK
  • Michelle K. Lupton
    Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK
  • Carol Brayne
    Institute of Public Health, University of Cambridge, Cambridge, UK
  • David C. Rubinsztein
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
  • Michael Gill
    Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland
  • Brian Lawlor
    Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland
  • Aoibhinn Lynch
    Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland
  • Kevin Morgan
    Human Genetics Group, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, UK
  • Kristelle S. Brown
    Human Genetics Group, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, UK
  • Peter A. Passmore
    Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
  • David Craig
    Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
  • Bernadette McGuinness
    Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
  • Stephen Todd
    Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
  • Janet A. Johnston
    Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
  • Clive Holmes
    Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
  • David Mann
    Neurodegeneration and Mental Health Research Group, School of Community Based Medicine, University of Manchester, Salford, UK
  • A. David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, John Radcliffe Hospital, Oxford, UK
  • Seth Love
    Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
  • Patrick G. Kehoe
    Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
  • John Hardy
    Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK
  • Simon Mead
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London
  • Nick Fox
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK
  • Martin Rossor
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK
  • John Collinge
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London
  • Wolfgang Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
  • Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
  • Heike Kölsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
  • Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
  • Britta Schürmann
    Department of Psychiatry, University of Bonn, Bonn, Germany
  • Hendrik van den Bussche
    Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany
  • Isabella Heuser
    Department of Psychiatry, Charit'e Berlin, Berlin, Germany
  • Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany
  • Jens Wiltfang
    LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany
  • Martin Dichgans
    Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany
  • Lutz Frölich
    Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
  • Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
  • Michael Hüll
    Ludwig-Maximilians-University, Department of Psychiatry, Munich, Germany
  • Dan Rujescu
    Ludwig-Maximilians-University, Department of Psychiatry, Munich, Germany
  • Alison M. Goate
    Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
  • John S. K Kauwe
    Department of Biology, Brigham Young University, Provo, Utah, USA
  • Carlos Cruchaga
    Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
  • Petra Nowotny
    Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
  • John C. Morris
    Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
  • Kevin Mayo
    Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
  • Gill Livingston
    Mental Health Unit, UCL, London, UK
  • Nicholas J. Bass
    Mental Health Unit, UCL, London, UK
  • Hugh Gurling
    Mental Health Unit, UCL, London, UK
  • Andrew McQuillin
    Mental Health Unit, UCL, London, UK
  • Rhian Gwilliam
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
  • Panagiotis Deloukas
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
  • Gail Davies
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
  • Sarah E. Harris
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
  • John M. Starr
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
  • Ian J. Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
  • Ammar Al-Chalabi
    MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK
  • Christopher E. Shaw
    MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK
  • Magda Tsolaki
    Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Andrew B. Singleton
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
  • Rita Guerreiro
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
  • Thomas W. Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
  • Markus M. Nöthen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
  • Susanne Moebus
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany
  • Karl-Heinz Jöckel
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany
  • Norman Klopp
    Institute of Epidemiology, Helmholtz Zentrum M¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
  • H-Erich Wichmann
    Institute of Epidemiology, Helmholtz Zentrum M¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
  • Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
  • V Shane Pankratz
    Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
  • Steven G. Younkin
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
  • Lesley Jones
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Peter A Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Michael C. O'Donovan
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Michael J. Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
  • Julie Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK

書誌事項

公開日
2012-01-25
権利情報
  • https://creativecommons.org/licenses/by-nc/4.0/
DOI
  • 10.3233/jad-2011-110824
公開者
SAGE Publications

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