Cobalt(III)/Chiral Carboxylic Acid‐Catalyzed Enantioselective Synthesis of Benzothiadiazine‐1‐oxides via C−H Activation
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- Yuki Hirata
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
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- Daichi Sekine
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
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- Yoshimi Kato
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
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- Luqing Lin
- Zhang Dayu School of Chemistry Dalian University of Technology Dalian 116024 P. R. China
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- Masahiro Kojima
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
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- Tatsuhiko Yoshino
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
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- Shigeki Matsunaga
- Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
書誌事項
- 公開日
- 2022-05-19
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/anie.202205341
- 10.1002/ange.202205341
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Among sulfoximine derivatives containing a chiral sulfur center, benzothiadiazine‐1‐oxides are important for applications in medicinal chemistry. Here, we report that the combination of an achiral cobalt(III) catalyst and a pseudo‐<jats:italic>C</jats:italic><jats:sub>2</jats:sub>‐symmetric H<jats:sub>8</jats:sub>‐binaphthyl chiral carboxylic acid enables the asymmetric synthesis of benzothiadiazine‐1‐oxides from sulfoximines and dioxazolones via enantioselective C−H bond cleavage. With the optimized protocol, benzothiadiazine‐1‐oxides with several functional groups can be accessed with high enantioselectivity.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 61 (28), e202205341-, 2022-05-19
Wiley