Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

DOI PDF 被引用文献140件
  • T R Mosmann
    DNAX Research Institute of Molecular and Cellular Biology. Inc. , 901 California Ave, Palo Alto, CA 94304
  • H Cherwinski
    DNAX Research Institute of Molecular and Cellular Biology. Inc. , 901 California Ave, Palo Alto, CA 94304
  • M W Bond
    DNAX Research Institute of Molecular and Cellular Biology. Inc. , 901 California Ave, Palo Alto, CA 94304
  • M A Giedlin
    DNAX Research Institute of Molecular and Cellular Biology. Inc. , 901 California Ave, Palo Alto, CA 94304
  • R L Coffman
    DNAX Research Institute of Molecular and Cellular Biology. Inc. , 901 California Ave, Palo Alto, CA 94304

書誌事項

公開日
1986-04-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.136.7.2348
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells (TH1) produced IL 2, interferon-gamma, GM-CSF, and IL 3 in response to antigen + presenting cells or to Con A, whereas type 2 helper T cells (TH2) produced IL 3, BSF1, and two other activities unique to the TH2 subset, a mast cell growth factor distinct from IL 3 and a T cell growth factor distinct from IL 2. Clones representing each type of T cell were characterized, and the pattern of lymphokine activities was consistent within each set. The secreted proteins induced by Con A were analyzed by biosynthetic labeling and SDS gel electrophoresis, and significant differences were seen between the two groups of T cell line. Both types of T cell grew in response to alternating cycles of antigen stimulation, followed by growth in IL 2-containing medium. Examples of both types of T cell were also specific for or restricted by the I region of the MHC, and the surface marker phenotype of the majority of both types was Ly-1+, Lyt-2-, L3T4+, Both types of helper T cell could provide help for B cells, but the nature of the help differed. TH1 cells were found among examples of T cell clones specific for chicken RBC and mouse alloantigens. TH2 cells were found among clones specific for mouse alloantigens, fowl gamma-globulin, and KLH. The relationship between these two types of T cells and previously described subsets of T helper cells is discussed.</jats:p>

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