Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion.**
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- Robert R. A. Bolt
- Department of Pharmaceutical and Biological Chemistry University College London (UCL) School of Pharmacy 29-39 Brunswick Square, Bloomsbury London WC1N 1AX UK
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- Sarah E. Raby‐Buck
- Department of Pharmaceutical and Biological Chemistry University College London (UCL) School of Pharmacy 29-39 Brunswick Square, Bloomsbury London WC1N 1AX UK
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- Katharine Ingram
- Syngenta, Jealott's Hill International Research Centre Bracknell, Berkshire RG42 6EY UK
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- Jamie A. Leitch
- Department of Pharmaceutical and Biological Chemistry University College London (UCL) School of Pharmacy 29-39 Brunswick Square, Bloomsbury London WC1N 1AX UK
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- Duncan L. Browne
- Department of Pharmaceutical and Biological Chemistry University College London (UCL) School of Pharmacy 29-39 Brunswick Square, Bloomsbury London WC1N 1AX UK
抄録
<jats:title>Abstract</jats:title><jats:p>The use of temperature‐controlled mechanochemistry to enable the mechanochemical nickel‐catalyzed Suzuki–Miyaura coupling is herein described. Transitioning from a capricious room‐temperature protocol, through to a heated, PID‐controlled programmable jar heater manifold was required to deliver an efficient method for the coupling of aryl sulfamates (derived from ubiquitous phenols) and aryl boronic acid species. Furthermore, this process is conducted using a base‐metal nickel catalyst, in the absence of bulk solvent, and in the absence of air/moisture sensitive reaction set‐ups. This methodology is showcased through translation to large‐scale twin‐screw extrusion methodology enabling 200‐fold scale increase, producing decagram quantities of C−C coupled material.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 61 (44), 2022-10-05
Wiley