IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

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  • Xiaoxiao Liu
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
  • Naru Sato
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Tomohiro Yabushita
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Jingmei Li
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
  • Yuhan Jia
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
  • Moe Tamura
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
  • Shuhei Asada
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Takeshi Fujino
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Tsuyoshi Fukushima
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Taishi Yonezawa
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
  • Yosuke Tanaka
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Tomofusa Fukuyama
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Akiho Tsuchiya
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Shiori Shikata
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Hiroyuki Iwamura
    FUJIFILM Corporation: Pharmaceutical Products Division Tokyo Japan
  • Chieko Kinouchi
    FUJIFILM Corporation: Bio Science & Engineering Laboratories Kanagawa Japan
  • Kensuke Komatsu
    FUJIFILM Corporation: Bio Science & Engineering Laboratories Kanagawa Japan
  • Satoshi Yamasaki
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Tatsuhiro Shibata
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Atsuo T Sasaki
    Division of Hematology and Oncology, Department of Internal Medicine University of Cincinnati Cincinnati OH USA
  • Janet Schibler
    Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Cincinnati OH USA
  • Mark Wunderlich
    Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Cincinnati OH USA
  • Eric O'Brien
    Division of Oncology, Department of Pediatrics, University of Cincinnati Cincinnati OH USA
  • Benjamin Mizukawa
    Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Cincinnati OH USA
  • James C Mulloy
    Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Cincinnati OH USA
  • Yuki Sugiura
    Department of Biochemistry Keio University School of Medicine Tokyo Japan
  • Hitoshi Takizawa
    Laboratory of Stem Cell Stress, International Research Center for Medical Sciences Kumamoto University Kumamoto Japan
  • Takuma Shibata
    Division of Innate Immunity, Department of Microbiology and Immunology The Institute of Medical Science, The University of Tokyo Tokyo Japan
  • Kensuke Miyake
    Division of Innate Immunity, Department of Microbiology and Immunology The Institute of Medical Science, The University of Tokyo Tokyo Japan
  • Toshio Kitamura
    Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan
  • Susumu Goyama
    Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan

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