Differences in antimicrobial components between bacterial culture‐positive and culture‐negative bovine clinical mastitis milk

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  • Yusaku Tsugami
    Graduate School of Integrated Sciences for Life Hiroshima University Hiroshima Japan
  • Tomoyuki Chiba
    Mzuzu Veterinary Clinic Shibecha Japan
  • Tetsu Obayashi
    Shikaoi Veterinary Clinic Tokachi NOSAI Shikaoi Japan
  • Hidetoshi Higuchi
    School of Veterinary Medicine Rakuno Gakuen University Ebetsu Japan
  • Atsushi Watanabe
    National Institute of Animal Health National Agriculture and Food Research Organization Sapporo Japan
  • Naoki Isobe
    Graduate School of Integrated Sciences for Life Hiroshima University Hiroshima Japan
  • Kazuhiro Kawai
    School of Veterinary Medicine Azabu University Kanagawa Japan

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<jats:title>Abstract</jats:title><jats:p>A bacterial culture of milk is the most common test to determine the presence of mastitis‐causing pathogens, which informs appropriate treatment. However, a certain proportion of clinical mastitis milk shows no growth of any mastitis‐causing pathogens. We hypothesized that bacterial culture‐negative clinical mastitis milk is associated with the activity of antimicrobial components contained in the milk. In this study, the differences in antimicrobial components (lactoferrin, transferrin, lysozyme, lactoperoxidase, and lingual antimicrobial peptide [LAP]) between bacterial culture‐positive and culture‐negative bovine clinical mastitis milk were investigated using Holstein cows. Our results showed that 37 out of 71 samples of clinical mastitis milk had negative bacterial cultures. The LAP concentration in bacterial culture‐negative milk was lower than that in positive milk (31.95 ± 1.64 nM vs. 42.85 ± 4.01 nM). In contrast, the lysozyme concentration in bacterial culture‐negative milk was higher than that in positive milk (0.76 ± 0.15 μg/ml vs. 0.42 ± 0.06 μg/ml). In conclusion, the concentration of antimicrobial components was different between bacterial culture‐positive and culture‐negative bovine clinical mastitis milk, which suggests that antimicrobial components are related to bacterial culture results.</jats:p>

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