Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center
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- Cheol Lee
- editor
書誌事項
- 公開日
- 2022-01
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1155/2022/6386606
- 公開者
- Wiley
この論文をさがす
説明
<jats:p><jats:italic>Introduction.</jats:italic> We compared the hemodynamics during general anesthesia with remimazolam and conventional anesthetics in patients with severe aortic stenosis (AS). <jats:italic>Methods.</jats:italic> This was a retrospective single‐center analysis. We reviewed the records of 42 patients who underwent transcatheter aortic valve implantation with a transfemoral artery approach under general anesthesia from January to December 2020. Patients were divided into three groups based on the general anesthetic used for (induction/maintenance) remimazolam/remimazolam (Group R/R), propofol/sevoflurane (Group P/S), and midazolam/propofol (Group M/P). Vasopressor use (ephedrine, phenylephrine, and noradrenaline) was compared among the groups. <jats:italic>Results.</jats:italic> The number of patients in each group was 15 (Group R/R), 13 (Group P/S), and 14 (Group M/P), with no significant difference in background characteristics and intraoperative vital signs. For anesthesia induction, doses of ephedrine and phenylephrine used were significantly lower in Group R/R (ephedrine [mg]: Group R/R 2 [0–4] vs. Group P/S 8 [8–12], <jats:italic>P</jats:italic> < 0.001, Group R/R vs. Group M/P 5 [0–15], <jats:italic>P</jats:italic> = 0.39; phenylephrine (mg): Group R/R 0 [0–0.08] vs. Group P/S 0.15 [0.10–0.20], <jats:italic>P</jats:italic> = 0.03, Group M/P 0.21 [0.04–0.40], <jats:italic>P</jats:italic> = 0.08). For anesthesia maintenance, the noradrenaline dose used was low in the Group R/R (noradrenaline [<jats:italic>μ</jats:italic>g/kg/min]: Group R/R 0.019 [0.015–0.039], Group P/S 0.042 [0.035–0.045], <jats:italic>P</jats:italic> = 0.02, Group M/P 0.048 [0.040–0.059], <jats:italic>P</jats:italic> < 0.01). <jats:italic>Conclusion.</jats:italic> In patients with severe AS, induction and maintenance of anesthesia with remimazolam resulted in less overall vasopressor use than conventional general anesthetics.</jats:p>
収録刊行物
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- BioMed Research International
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BioMed Research International 2022 (1), 6386606-, 2022-01
Wiley