Large-scale mapping of positional changes of hypoxia-responsive genes upon activation
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- Koh Nakayama
- Oxygen Biology Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan
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- Sigal Shachar
- Cell Biology of Genomes Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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- Elizabeth H. Finn
- Cell Biology of Genomes Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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- Hiroyuki Sato
- Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan
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- Akihiro Hirakawa
- Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan
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- Tom Misteli
- Cell Biology of Genomes Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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- Karsten Weis
- editor
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説明
<jats:p>A high-throughput imaging platform was used to perform a large-scale analysis of the spatial location of hypoxia-responsive genes. The location of some genes changed upon hypoxia; however, they did not correlate with the extent of their activation, indicating that gene positions and expression are not strictly linked in hypoxic gene activation.</jats:p>
収録刊行物
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- Molecular Biology of the Cell
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Molecular Biology of the Cell 33 (8), 2022-07-01
American Society for Cell Biology (ASCB)
