Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease
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- Tatsuhiro Terada
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Joseph Therriault
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Min Su Kang
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Melissa Savard
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Tharick Ali Pascoal
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Firoza Lussier
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Cecile Tissot
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Yi‐Ting Wang
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Andrea Benedet
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Nina Margherita Poltronetti
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Julie Ottoy
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Jaime Frenandez Arias
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Gleb Bezgin
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
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- Takashi Matsudaira
- Department of Biofunctional Imaging Preeminent Medical Photonics Education & Research Center Hamamatsu University School of Medicine Hamamatsu Japan
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- Tomoyasu Bunai
- Department of Biofunctional Imaging Preeminent Medical Photonics Education & Research Center Hamamatsu University School of Medicine Hamamatsu Japan
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- Tomokazu Obi
- Department of Neurology Shizuoka Institute of Epilepsy and Neurological Disorders Shizuoka Japan
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- Hideo Tsukada
- Central Research Laboratory Hamamatsu Photonics KK Hamamatsu Japan
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- Yasuomi Ouchi
- Department of Biofunctional Imaging Preeminent Medical Photonics Education & Research Center Hamamatsu University School of Medicine Hamamatsu Japan
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- Pedro Rosa‐Neto
- Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest‐de‐l'Île‐de‐Montréal Montreal QC Canada
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and purpose</jats:title><jats:p>Abnormal mitochondrial metabolism has been described in the Alzheimer's disease (AD) brain. However, the relationship between AD pathophysiology and key mitochondrial processes remains elusive. The purpose of this study was to investigate whether mitochondrial complex I dysfunction is associated with amyloid aggregation or glucose metabolism and brain atrophy in patients with mild AD using positron emission tomography (PET).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Amyloid‐ and tau‐positive symptomatic AD patients with clinical dementia rating 0.5 or 1 (<jats:italic>N</jats:italic> = 30; mean age ± standard deviation: 71.8 ± 7.6 years) underwent magnetic resonance imaging and PET scans with [<jats:sup>18</jats:sup>F]2‐tert‐butyl‐4‐chloro‐5–2H‐pyridazin‐3‐one (BCPP‐EF), [<jats:sup>11</jats:sup>C]Pittsburgh Compound‐B (PiB) and [<jats:sup>18</jats:sup>F]fluorodeoxyglucose (FDG) to assess brain atrophy, mitochondrial complex I dysfunction, amyloid deposition, and glucose metabolism, respectively. Local cortical associations among these biomarkers and gray matter volume were evaluated with voxel‐based regressions models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>[<jats:sup>18</jats:sup>F]BCPP‐EF standardized uptake value ratio (SUVR) was positively correlated with [<jats:sup>18</jats:sup>F]FDG SUVR in the widespread brain area, while its associations with gray matter volume were restricted to the parahippocampal gyrus. Reductions in [<jats:sup>18</jats:sup>F]BCPP‐EF SUVR were associated with domain‐specific cognitive performance. We did not observe regional associations between mitochondrial dysfunction and amyloid burden.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In symptomatic cases, although mitochondrial complex I reduction is linked to a wide range of downstream neurodegenerative processes such as hypometabolism, atrophy, and cognitive decline, a link to amyloid was not observable. The data presented here support [<jats:sup>18</jats:sup>F]BCPP‐EF as an excellent imaging tool to investigate mitochondrial dysfunction in AD.</jats:p></jats:sec>
収録刊行物
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- European Journal of Neurology
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European Journal of Neurology 29 (5), 1324-1334, 2022-01-22
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360017280653704704
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- ISSN
- 14681331
- 13515101
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- データソース種別
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- Crossref
- KAKEN