Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies

DOI Web Site 参考文献28件 オープンアクセス
  • Cyprian Chunkang Mikwa
    Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
  • Gwendoline Mochia Toh-Boyo
    Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
  • Romanus Nyako Njong
    Department of Fundamental Sciences, Higher Technical Teacher Training College, The University of Bamenda, Bambili, PO Box 39, Cameroon
  • Bridget Ndosiri Ndoye
    Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, PO Box 812, Cameroon
  • Christophe Adrien Ndamyabera
    Department of Chemistry, Centre for Supramolecular Chemistry Research, University of Cape Town, Rondebosch 7701, South Africa
  • Natsuki Katsuumi
    Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan
  • Yuta Mitani
    Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan
  • Emmanuel Ngwang Nfor
    Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
  • Takashiro Akitsu
    Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan

抄録

<jats:p>Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, V = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM.</jats:p>

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