Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies
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- Cyprian Chunkang Mikwa
- Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
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- Gwendoline Mochia Toh-Boyo
- Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
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- Romanus Nyako Njong
- Department of Fundamental Sciences, Higher Technical Teacher Training College, The University of Bamenda, Bambili, PO Box 39, Cameroon
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- Bridget Ndosiri Ndoye
- Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, PO Box 812, Cameroon
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- Christophe Adrien Ndamyabera
- Department of Chemistry, Centre for Supramolecular Chemistry Research, University of Cape Town, Rondebosch 7701, South Africa
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- Natsuki Katsuumi
- Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan
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- Yuta Mitani
- Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan
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- Emmanuel Ngwang Nfor
- Department of Chemistry, Faculty of Science, University of Buea, Buea, PO Box 63, Cameroon
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- Takashiro Akitsu
- Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-Ku, Tokyo 162-8601, Japan
抄録
<jats:p>Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, V = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM.</jats:p>
収録刊行物
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- European Journal of Chemistry
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European Journal of Chemistry 13 (1), 63-68, 2022-03-31
European Journal of Chemistry
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詳細情報 詳細情報について
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- CRID
- 1360017280658207488
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- ISSN
- 21532257
- 21532249
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- データソース種別
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- Crossref
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