Compartment-specific tuning of dendritic feature selectivity by intracellular Ca <sup>2+</sup> release

DOI Web Site 参考文献84件
  • Justin K. O’Hare
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Kevin C. Gonzalez
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Stephanie A. Herrlinger
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Yusuke Hirabayashi
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
  • Victoria L. Hewitt
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Heike Blockus
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Miklos Szoboszlay
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Sebi V. Rolotti
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Tristan C. Geiller
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Adrian Negrean
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Vikas Chelur
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Franck Polleux
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.
  • Attila Losonczy
    Department of Neuroscience, Columbia University, New York, NY 10027, USA.

説明

<jats:p>Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum has long been thought to shape these mechanisms. However, ICR has not been investigated in mammalian neurons in vivo. We combined electroporation of single CA1 pyramidal neurons, simultaneous imaging of dendritic and somatic activity during spatial navigation, optogenetic place field induction, and acute genetic augmentation of ICR cytosolic impact to reveal that ICR supports the establishment of dendritic feature selectivity and shapes integrative properties determining output-level receptive fields. This role for ICR was more prominent in apical than in basal dendrites. Thus, ICR cooperates with circuit-level architecture in vivo to promote the emergence of behaviorally relevant plasticity in a compartment-specific manner.</jats:p>

収録刊行物

  • Science

    Science 375 (6586), 2022-03-18

    American Association for the Advancement of Science (AAAS)

参考文献 (84)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ