Multiple sclerosis: Possibility of a gut environment-induced disease
書誌事項
- 公開日
- 2019-11
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.neuint.2019.104475
- 公開者
- Elsevier BV
この論文をさがす
説明
Multiple sclerosis is a putative autoimmune disease of the central nervous system, a representative disease of 'neuroimmunology.' We now understand that gut microbiota constitutes an integral part of our body and play critical roles in various neurological diseases with which no intestinal pathology was previously associated. In fact, several reports from Japan, North America, and Europe confirmed dysbiosis of the gut microbiome in MS patients. Given the increase in the prevalence of MS worldwide, especially in Japan, some previously unknown causal environmental factors needed to be identified to inhibit the development of MS in future generations. In this review, we will introduce recent key topics related to MS pathogenesis and immune cells linking gut and brain, and then summarize studies on gut microbiome in MS and its mouse model. Lastly, we will discuss the potential role of diet in the development of MS and propose a hypothesis that could explain the dramatic increase in the number of patients suffering with MS in Japan in the past few decades.
収録刊行物
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- Neurochemistry International
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Neurochemistry International 130 104475-, 2019-11
Elsevier BV