Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure
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- Jun Hirayama
- Department of Clinical Engineering, Faculty of Health Sciences & Division of Health Sciences, Graduate School of Sustainable Systems Science Komatsu University Komatsu Japan
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- Atsuhiko Hattori
- Department of Biology, College of Liberal Arts and Sciences Tokyo Medical and Dental University Ichikawa Japan
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- Akihisa Takahashi
- Gunma University Heavy Ion Medical Center Maebashi Japan
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- Yukihiro Furusawa
- Department of Pharmaceutical Engineering, Faculty of Engineering Toyama Prefectural University Toyama Japan
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- Yoshiaki Tabuchi
- Life Science Research Center University of Toyama Toyama Japan
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- Masahiro Shibata
- Department of Biology, College of Liberal Arts and Sciences Tokyo Medical and Dental University Ichikawa Japan
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- Aiko Nagamatsu
- Japan Aerospace Exploration Agency Tsukuba Japan
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- Sachiko Yano
- Japan Aerospace Exploration Agency Tsukuba Japan
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- Yusuke Maruyama
- Department of Biology, College of Liberal Arts and Sciences Tokyo Medical and Dental University Ichikawa Japan
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- Hajime Matsubara
- Noto Center for Fisheries Science and Technology Kanazawa University Noto‐cho, Ishikawa Japan
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- Toshio Sekiguchi
- Noto Marine Laboratory, Institute of Nature and Environmental Technology Kanazawa University Noto‐cho Japan
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- Nobuo Suzuki
- Noto Marine Laboratory, Institute of Nature and Environmental Technology Kanazawa University Noto‐cho Japan
書誌事項
- 公開日
- 2022-10-17
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/jpi.12834
- 公開者
- Wiley
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説明
<jats:title>Abstract</jats:title><jats:p>Exposure to the space environment induces a number of pathophysiological outcomes in astronauts, including bone demineralization, sleep disorders, circadian clock dysregulation, cardiovascular and metabolic dysfunction, and reduced immune system function. A recent report describing experiments aboard the Space Shuttle mission, STS‐132, showed that the level of melatonin, a hormone that provides the biochemical signal of darkness, was decreased during microgravity in an in vitro culture model. Additionally, abnormal lighting conditions in outer space, such as low light intensity in orbital spacecraft and the altered 24‐h light–dark cycles, may result in the dysregulation of melatonin rhythms and the misalignment of the circadian clock from sleep and work schedules in astronauts. Studies on Earth have demonstrated that melatonin regulates various physiological functions including bone metabolism. These data suggest that the abnormal regulation of melatonin in outer space may contribute to pathophysiological conditions of astronauts. In addition, experiments with high‐linear energy transfer radiation, a ground‐based model of space radiation, showed that melatonin may serve as a protectant against space radiation. Gene expression profiling using an in vitro culture model exposed to space flight during the STS‐132 mission, showed that space radiation alters the expression of DNA repair and oxidative stress response genes, indicating that melatonin counteracts the expression of these genes responsive to space radiation to promote cell survival. These findings implicate the use of exogenous melatonin and the regulation of endogenous melatonin as countermeasures for the physiological consequences of space flight.</jats:p>
収録刊行物
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- Journal of Pineal Research
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Journal of Pineal Research 74 (1), e12834-, 2022-10-17
Wiley