Regioselective anti-Silyllithiation of Propargylic Amines

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公開日
2023-03-06
資源種別
journal article
DOI
  • 10.1055/a-2047-8456
公開者
Georg Thieme Verlag KG

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説明

<jats:title>Abstract</jats:title><jats:p>The regioselective anti-silyllithiation of propargylic amines is developed to facilitate the efficient synthesis of alkenylsilanes. This reaction generates an alkenyllithium intermediate that is stabilized by the formation of a five-membered cyclic structure through intramolecular coordination of the nitrogen functional group. Upon subsequent treatment with an electrophile, the alkenyllithium intermediate is further functionalized to afford tetrasubstituted allylic amines bearing a β-silicon substituent.</jats:p>

収録刊行物

  • Synlett

    Synlett 35 (04), 419-422, 2023-03-06

    Georg Thieme Verlag KG

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