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Regioselective anti-Silyllithiation of Propargylic Amines
Bibliographic Information
- Published
- 2023-03-06
- Resource Type
- journal article
- DOI
-
- 10.1055/a-2047-8456
- Publisher
- Georg Thieme Verlag KG
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Description
<jats:title>Abstract</jats:title><jats:p>The regioselective anti-silyllithiation of propargylic amines is developed to facilitate the efficient synthesis of alkenylsilanes. This reaction generates an alkenyllithium intermediate that is stabilized by the formation of a five-membered cyclic structure through intramolecular coordination of the nitrogen functional group. Upon subsequent treatment with an electrophile, the alkenyllithium intermediate is further functionalized to afford tetrasubstituted allylic amines bearing a β-silicon substituent.</jats:p>
Journal
-
- Synlett
-
Synlett 35 (04), 419-422, 2023-03-06
Georg Thieme Verlag KG
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Details 詳細情報について
-
- CRID
- 1360017282463062400
-
- ISSN
- 14372096
- 09365214
-
- Article Type
- journal article
-
- Data Source
-
- Crossref
- KAKEN
