-
- Jung Woo Park
- Center for Reproduction, Development, and Aging and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, People's Republic of China
-
- Siyi Fu
- Center for Reproduction, Development, and Aging and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, People's Republic of China
-
- Borong Huang
- Center for Reproduction, Development, and Aging and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, People's Republic of China
-
- Ren-He Xu
- Center for Reproduction, Development, and Aging and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, People's Republic of China
説明
<jats:title>Abstract</jats:title> <jats:p>The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and other lineages are known to be controlled by various extrinsic and intrinsic signals. The dysregulation of the MSC differentiation balance has been linked to several pathophysiological conditions, including obesity and osteoporosis. Previous research of the molecular mechanisms governing MSC differentiation has mostly focused on transcriptional regulation. However, recent findings are revealing the underrated role of alternative splicing (AS) in MSC differentiation and functions. In this review, we discuss recent progress in elucidating the regulatory roles of AS in MSC differentiation. We catalogue and highlight the key AS events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.</jats:p> <jats:sec> <jats:title /> </jats:sec>
収録刊行物
-
- Stem Cells
-
Stem Cells 38 (10), 1229-1240, 2020-07-15
Oxford University Press (OUP)
