Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
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- Jin He
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Peiwen Zhang
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Linyuan Shen
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Lili Niu
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Ya Tan
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Lei Chen
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Ye Zhao
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Lin Bai
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Xiaoxia Hao
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Xuewei Li
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Shunhua Zhang
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
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- Li Zhu
- College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
説明
<jats:p>Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 21 (17), 6356-, 2020-09-02
MDPI AG