<i>TP53</i> mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML
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- Olga K. Weinberg
- Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX;
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- Alexa Siddon
- Department of Pathology, Yale School of Medicine, New Haven, CT;
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- Yazan F. Madanat
- Department of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX;
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- Jeffrey Gagan
- Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX;
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- Daniel A. Arber
- Department of Pathology and Laboratory Medicine, University of Chicago, Chicago, IL;
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- Paola Dal Cin
- Department of Pathology, Brigham and Women’s Hospital, Boston, MA;
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- Damodaran Narayanan
- Department of Pathology, Brigham and Women’s Hospital, Boston, MA;
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- Madhu M. Ouseph
- Department of Pathology, Weill Cornell Medical College, New York, NY;
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- Jason H. Kurzer
- Department of Pathology, Stanford University Medical Center, Palo Alto, CA; and
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- Robert P. Hasserjian
- Department of Pathology, Massachusetts General Hospital, Boston, MA
抄録
<jats:title>Abstract</jats:title> <jats:p>A subset of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) show complex karyotype (CK), and these cases include a relatively high proportion of cases of therapy-related myeloid neoplasms and TP53 mutations. We aimed to evaluate the clinicopathologic features of outcome of 299 AML and MDS patients with CK collected from multiple academic institutions. Mutations were present in 287 patients (96%), and the most common mutation detected was in TP53 gene (247, 83%). A higher frequency of TP53 mutations was present in therapy-related cases (P = .008), with a trend for worse overall survival (OS) in therapy-related patients as compared with de novo disease (P = .08) and within the therapy-related group; the presence of TP53 mutation strongly predicted for worse outcome (P = .0017). However, there was no difference in survival between CK patients based on categorization of AML vs MDS (P = .96) or presence of absence of circulating blasts ≥1% (P = .52). TP53-mutated patients presented with older age (P = .06) and lower hemoglobin levels (P = .004) and marrow blast counts (P = .02) compared with those with CK lacking TP53 mutation. Multivariable analysis identified presence of multihit TP53 mutation as strongest predictor of worse outcome, whereas neither a diagnosis of AML vs MDS nor therapy-relatedness independently influenced OS. Our findings suggest that among patients with MDS and AML, the presence of TP53 mutation (in particular multihit TP53 mutation) in the context of CK identifies a homogeneously aggressive disease, irrespective of the blast count at presentation or therapy-relatedness. The current classification of these cases into different disease categories artificially separates a single biologic disease entity.</jats:p>
収録刊行物
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- Blood Advances
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Blood Advances 6 (9), 2847-2853, 2022-05-05
American Society of Hematology