The IntAct database: efficient access to fine-grained molecular interaction data

  • Noemi del Toro
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Anjali Shrivastava
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Eliot Ragueneau
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Birgit Meldal
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Colin Combe
    Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK
  • Elisabet Barrera
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Livia Perfetto
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Karyn How
    UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
  • Prashansa Ratan
    UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
  • Gautam Shirodkar
    UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
  • Odilia Lu
    UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
  • Bálint Mészáros
    Gibson Group, European Molecular Biology Laboratory, Heidelberg 69117, Germany
  • Xavier Watkins
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Sangya Pundir
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Luana Licata
    Bioinformatics and Computational Biology Unit, Dept. of Molecular Biology, University of Rome Tor Vergata, Rome, Italy
  • Marta Iannuccelli
    Bioinformatics and Computational Biology Unit, Dept. of Molecular Biology, University of Rome Tor Vergata, Rome, Italy
  • Matteo Pellegrini
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
  • Maria Jesus Martin
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Simona Panni
    Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende, Italy
  • Margaret Duesbury
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Sylvain D Vallet
    ICBMS UMR CNRS 5246, University Lyon 1, Lyon, Villeurbanne 69622, France
  • Juri Rappsilber
    Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK
  • Sylvie Ricard-Blum
    ICBMS UMR CNRS 5246, University Lyon 1, Lyon, Villeurbanne 69622, France
  • Gianni Cesareni
    Bioinformatics and Computational Biology Unit, Dept. of Molecular Biology, University of Rome Tor Vergata, Rome, Italy
  • Lukasz Salwinski
    UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
  • Sandra Orchard
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Pablo Porras
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Kalpana Panneerselvam
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK
  • Henning Hermjakob
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK

抄録

<jats:title>Abstract</jats:title><jats:p>The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.</jats:p>

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