Continuous Wave EPR Oximetric Imaging at 300 MHz Using Radiofrequency Power Saturation Effects
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- Yukihiro Hama
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Ken-Ichiro Matsumoto
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Ramachandran Murugesan
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Sankaran Subramanian
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Nallathamby Devasahayam
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Janusz W. Koscielniak
- Laboratory of Proteomics and Analytical Technologies, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland.
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- Fuminori Hyodo
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- John A. Cook
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- James B. Mitchell
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
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- Murali C. Krishna
- Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
書誌事項
- 公開日
- 2007-10
- DOI
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- 10.1089/ars.2007.1720
- 公開者
- SAGE Publications
この論文をさがす
説明
A novel continuous wave (CW), radiofrequency (RF), electron paramagnetic resonance (EPR) oximetric imaging technique is proposed, based on the influence of oxygen concentration on the RF power saturation of the EPR resonance. A linear relationship is demonstrated between the partial oxygen pressure (pO(2)) and the normalized signal intensity (I(N)), defined as, I(N) = (I(HP) - I(LP))/I(LP), where I(LP) and I(HP) refer to signal intensities at low (P(L)) and high (P(H)) RF power levels, respectively. A formula for the determination of pO(2), derived on the basis of the experimental results, reliably estimated various oxygen concentrations in a five-tube phantom. This new technique was time-efficient and also avoided the missing angle problem associated with conventional spectral-spatial CW EPR oximetric imaging. In vivo power saturation oximetric imaging in a tumor bearing mouse clearly depicted the hypoxic foci within the tumor.
収録刊行物
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- Antioxidants & Redox Signaling
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Antioxidants & Redox Signaling 9 (10), 1709-1716, 2007-10
SAGE Publications