A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations

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  • Lavinia J. González Aparicio
    Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, USA
  • Carolina B. López
    Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, USA
  • Sébastien A. Felt
    Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, USA

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<jats:p>Negative-sense RNA virus populations are composed of diverse viral components that interact to form a community and shape the outcome of virus infections. At the genomic level, RNA virus populations consist not only of a homogeneous population of standard viral genomes but also of an extremely large number of genome variants, termed viral quasispecies, and nonstandard viral genomes, which include copy-back viral genomes, deletion viral genomes, mini viral RNAs, and hypermutated RNAs.</jats:p>

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