Lack of CD8 <sup>+</sup> T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer
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- Brendan L. Horton
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Duncan M. Morgan
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Noor Momin
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Maria Zagorulya
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Elen Torres-Mejia
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Vidit Bhandarkar
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- K. Dane Wittrup
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- J. Christopher Love
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
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- Stefani Spranger
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
抄録
<jats:p> A lung cancer–specific form of CD8 <jats:sup>+</jats:sup> T cell dysfunction is established during T cell priming and contributes to ICB resistance. </jats:p>
収録刊行物
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- Science Immunology
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Science Immunology 6 (64), eabi8800-, 2021-10-29
American Association for the Advancement of Science (AAAS)