Divergent sensory and immune gene evolution in sea turtles with contrasting demographic and life histories
-
- Blair P. Bentley
- Department of Environmental Conservation, University of Massachusetts, Amherst, MA 01003
-
- Tomás Carrasco-Valenzuela
- Evolutionary Genetics Department, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany
-
- Elisa K. S. Ramos
- Evolutionary Genetics Department, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany
-
- Harvinder Pawar
- Institut de Biologia Evolutiva, (CSIC-Universitat Pompeu Fabra), PRBB, Barcelona, Catalonia 08003, Spain
-
- Larissa Souza Arantes
- Evolutionary Genetics Department, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany
-
- Alana Alexander
- Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand
-
- Shreya M. Banerjee
- Department of Environmental Conservation, University of Massachusetts, Amherst, MA 01003
-
- Patrick Masterson
- National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894
-
- Martin Kuhlwilm
- Institut de Biologia Evolutiva, (CSIC-Universitat Pompeu Fabra), PRBB, Barcelona, Catalonia 08003, Spain
-
- Martin Pippel
- Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
-
- Jacquelyn Mountcastle
- Vertebrate Genome Lab, The Rockefeller University, New York, NY 10065
-
- Bettina Haase
- Vertebrate Genome Lab, The Rockefeller University, New York, NY 10065
-
- Marcela Uliano-Silva
- Evolutionary Genetics Department, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany
-
- Giulio Formenti
- Vertebrate Genome Lab, The Rockefeller University, New York, NY 10065
-
- Kerstin Howe
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- William Chow
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- Alan Tracey
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- Ying Sims
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- Sarah Pelan
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- Jonathan Wood
- Tree of Life, Wellcome Sanger Institute, Cambridge CB10 1SA, UK
-
- Kelsey Yetsko
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida, St. Augustine, FL 32080
-
- Justin R. Perrault
- Loggerhead Marinelife Center, Juno Beach, FL 33408
-
- Kelly Stewart
- Marine Mammal and Turtle Division, Southwest Fisheries Science Center, National Oceanic and Atmospheric Administration, La Jolla, CA 92037
-
- Scott R. Benson
- Marine Mammal and Turtle Division, Southwest Fisheries Science Center, National Oceanic and Atmospheric Administration, La Jolla, CA 92037
-
- Yaniv Levy
- Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Haifa 3498838, Israel
-
- Erica V. Todd
- School of Life and Environmental Sciences, Deakin University, Queenscliff, VIC 3225, Australia
-
- H. Bradley Shaffer
- Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095
-
- Peter Scott
- Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095
-
- Brian T. Henen
- Environmental Affairs, Marine Air Ground Task Force and Training Command, Marine Corps Air Ground Combat Center, Twentynine Palms, CA 92278
-
- Robert W. Murphy
- Centre for Biodiversity Royal Ontario Museum, Toronto, ON M5S 2C6, Canada
-
- David W. Mohr
- Genetic Resources Core Facility, School of Medicine McKusick-Nathans Department of Genetic Medicine Johns Hopkins University, Baltimore, MD 21287
-
- Alan F. Scott
- Genetic Resources Core Facility, School of Medicine McKusick-Nathans Department of Genetic Medicine Johns Hopkins University, Baltimore, MD 21287
-
- David J. Duffy
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida, St. Augustine, FL 32080
-
- Neil J. Gemmell
- Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand
-
- Alexander Suh
- School of Biological Sciences, University of East Anglia, Norwich NR4 7TU, UK
-
- Sylke Winkler
- Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
-
- Françoise Thibaud-Nissen
- National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894
-
- Mariana F. Nery
- Department of Genetics, Evolution, Microbiology and Immunology, State University of Campinas, Campinas 13083-970, Brazil
-
- Tomas Marques-Bonet
- Institut de Biologia Evolutiva, (CSIC-Universitat Pompeu Fabra), PRBB, Barcelona, Catalonia 08003, Spain
-
- Agostinho Antunes
- Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto 4450-208, Portugal
-
- Yaron Tikochinski
- Faculty of Marine Sciences, Ruppin Academic Center, Michmoret 4025000, Israel
-
- Peter H. Dutton
- Marine Mammal and Turtle Division, Southwest Fisheries Science Center, National Oceanic and Atmospheric Administration, La Jolla, CA 92037
-
- Olivier Fedrigo
- Vertebrate Genome Lab, The Rockefeller University, New York, NY 10065
-
- Eugene W. Myers
- Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
-
- Erich D. Jarvis
- Vertebrate Genome Lab, The Rockefeller University, New York, NY 10065
-
- Camila J. Mazzoni
- Evolutionary Genetics Department, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany
-
- Lisa M. Komoroske
- Department of Environmental Conservation, University of Massachusetts, Amherst, MA 01003
抄録
<jats:p> Sea turtles represent an ancient lineage of marine vertebrates that evolved from terrestrial ancestors over 100 Mya. The genomic basis of the unique physiological and ecological traits enabling these species to thrive in diverse marine habitats remains largely unknown. Additionally, many populations have drastically declined due to anthropogenic activities over the past two centuries, and their recovery is a high global conservation priority. We generated and analyzed high-quality reference genomes for the leatherback ( <jats:italic>Dermochelys coriacea</jats:italic> ) and green ( <jats:italic>Chelonia mydas</jats:italic> ) turtles, representing the two extant sea turtle families. These genomes are highly syntenic and homologous, but localized regions of noncollinearity were associated with higher copy numbers of immune, zinc-finger, and olfactory receptor (OR) genes in green turtles, with ORs related to waterborne odorants greatly expanded in green turtles. Our findings suggest that divergent evolution of these key gene families may underlie immunological and sensory adaptations assisting navigation, occupancy of neritic versus pelagic environments, and diet specialization. Reduced collinearity was especially prevalent in microchromosomes, with greater gene content, heterozygosity, and genetic distances between species, supporting their critical role in vertebrate evolutionary adaptation. Finally, diversity and demographic histories starkly contrasted between species, indicating that leatherback turtles have had a low yet stable effective population size, exhibit extremely low diversity compared with other reptiles, and harbor a higher genetic load compared with green turtles, reinforcing concern over their persistence under future climate scenarios. These genomes provide invaluable resources for advancing our understanding of evolution and conservation best practices in an imperiled vertebrate lineage. </jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 120 (7), 2023-02-07
Proceedings of the National Academy of Sciences