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- Hai-Qing Tu
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Sen Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Yu-Ling Xu
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Yu-Cheng Zhang
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Pei-Yao Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Li-Yun Liang
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Guang-Ping Song
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Xiao-Xiao Jian
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Min Wu
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Zeng-Qing Song
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Ting-Ting Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Huai-Bin Hu
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Jin-Feng Yuan
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Xiao-Lin Shen
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Jia-Ning Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Qiu-Ying Han
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Kai Wang
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Tao Zhang
- Laboratory Animal Center, Academy of Military Medical Sciences, Beijing, China.
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- Tao Zhou
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Ai-Ling Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Xue-Min Zhang
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
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- Hui-Yan Li
- Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, China.
抄録
<jats:p>The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia in neuromedin S–producing (NMS) neurons exhibit pronounced circadian rhythmicity in abundance and length. Genetic ablation of ciliogenesis in NMS neurons enabled a rapid phase shift of the internal clock under jet-lag conditions. The circadian rhythms of individual neurons in cilia-deficient SCN slices lost their coherence after external perturbations. Rhythmic cilia changes drive oscillations of Sonic Hedgehog (Shh) signaling and clock gene expression. Inactivation of Shh signaling in NMS neurons phenocopied the effects of cilia ablation. Thus, cilia-Shh signaling in the SCN aids intercellular coupling.</jats:p>
収録刊行物
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- Science
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Science 380 (6648), 972-979, 2023-06-02
American Association for the Advancement of Science (AAAS)