Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
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- Merel C. Postema
- Language and Genetics Department Max Planck Institute for Psycholinguistics Nijmegen The Netherlands
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- Martine Hoogman
- Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands
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- Sara Ambrosino
- NICHE lab Department of Psychiatry University Medical Center Utrecht Brain Center Utrecht University Utrecht The Netherlands
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- Philip Asherson
- Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany
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- Cibele E. Bandeira
- Adulthood ADHD Outpatient Program (ProDAH) Clinical Research Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
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- Alexandr Baranov
- Research Institute of Pediatrics and Child Health of Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science and Higher Education of the Russian Federation Moscow Russia
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- Claiton H.D. Bau
- Adulthood ADHD Outpatient Program (ProDAH) Clinical Research Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
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- Sarah Baumeister
- Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany
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- Ramona Baur‐Streubel
- Department of Biological Psychology Clinical Psychology and Psychotherapy University of Würzburg Würzburg Germany
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- Mark A. Bellgrove
- Turner Institute for Brain and Mental Health and School of Psychological Sciences Monash University Melbourne Vic. Australia
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- Joseph Biederman
- Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD Boston MA USA
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- Janita Bralten
- Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands
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- Daniel Brandeis
- Department of Child and Adolescent Psychiatry and Psychotherapy Psychiatric Hospital University of Zurich Zurich Switzerland
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- Silvia Brem
- The Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich Switzerland
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- Jan K. Buitelaar
- Department of Cognitive Neuroscience Donders Institute for Brain, Cognition and Behaviour Radboudumc Nijmegen The Netherlands
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- Geraldo F. Busatto
- Laboratory of Psychiatric Neuroimaging (LIM‐21 Department and Institute of Psychiatry Hospital das Clinicas HCFMUSP Faculty of Medicine University of São Paulo Sao Paulo Sao Paulo Brazil
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- Francisco X. Castellanos
- Department of Child and Adolescent Psychiatry NYU Grossman School of Medicine New York NY USA
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- Mara Cercignani
- Department of Neuroscience Brighton and Sussex Medical School Falmer, Brighton UK
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- Tiffany M. Chaim‐Avancini
- Laboratory of Psychiatric Neuroimaging (LIM‐21 Department and Institute of Psychiatry Hospital das Clinicas HCFMUSP Faculty of Medicine University of São Paulo Sao Paulo Sao Paulo Brazil
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- Kaylita C. Chantiluke
- Department of Child and Adolescent Psychiatry Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- Anastasia Christakou
- Department of Child and Adolescent Psychiatry Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- David Coghill
- Departments of Paediatrics and Psychiatry University of Melbourne Melbourne Vic. Australia
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- Annette Conzelmann
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy University Hospital of Tübingen Tübingen Germany
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- Ana I. Cubillo
- Department of Child and Adolescent Psychiatry Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- Renata B. Cupertino
- Adulthood ADHD Outpatient Program (ProDAH) Clinical Research Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
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- Patrick de Zeeuw
- NICHE Lab Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands
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- Alysa E. Doyle
- Department of Psychiatry Massachusetts General Hospital Harvard Medical School Boston MA USA
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- Sarah Durston
- NICHE Lab Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands
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- Eric A. Earl
- Department of Behavioral Neuroscience Oregon Health & Science University Portland OR USA
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- Jeffery N. Epstein
- Division of Behavioral Medicine and Clinical Psychology Cincinnati Children’s Hospital Medical Center Cincinnati OH USA
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- Thomas Ethofer
- Clinic for Psychiatry/Psychotherapy Tübingen/Department for Biomedical Magnetic Resonance Tübingen Germany
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- Damien A. Fair
- Department of Behavioral Neuroscience Oregon Health & Science University Portland OR USA
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- Andreas J. Fallgatter
- Department of Psychiatry and Psychotherapy University Hospital of Tuebingen Tuebingen Germany
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- Stephen V. Faraone
- Departments of Psychiatry and of Neuroscience and Physiology SUNY Upstate Medical University Syracuse NY USA
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- Thomas Frodl
- Department of Psychiatry and Psychotherapy Otto von Guericke University Magdeburg Germany
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- Matt C. Gabel
- Department of Neuroscience Brighton and Sussex Medical School Falmer, Brighton UK
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- Tinatin Gogberashvili
- Laboratory of Neurology and Cognitive Health National Medical Research Center for Children's Health Moscow Russia
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- Eugenio H. Grevet
- Adulthood ADHD Outpatient Program (ProDAH) Clinical Research Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
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- Jan Haavik
- Department of Biomedicine K.G. Jebsen Centre for Neuropsychiatric Disorders University of Bergen Bergen Norway
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- Neil A. Harrison
- Department of Neuroscience Brighton and Sussex Medical School Falmer, Brighton UK
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- Catharina A. Hartman
- Department of Psychiatry Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE) University Medical Center Groningen University of Groningen Groningen The Netherlands
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- Dirk J. Heslenfeld
- Faculty of Behavioural and Movement Sciences Vrije Universiteit Amsterdam Amsterdam The Netherlands
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- Pieter J. Hoekstra
- Department of Child and Adolescent Psychiatry University Medical Center Groningen University of Groningen Groningen The Netherlands
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- Sarah Hohmann
- Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany
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- Marie F. Høvik
- Division of Psychiatry Haukeland University Hospital Bergen Norway
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- Terry L. Jernigan
- Center for Human Development UC San Diego La Jolla CA USA
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- Bernd Kardatzki
- Department of Biomedical Magnetic Resonance University of Tuebingen Tuebingen Germany
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- Georgii Karkashadze
- Research Institute of Pediatrics and Child Health of Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science and Higher Education of the Russian Federation Moscow Russia
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- Clare Kelly
- School of Psychology and Department of Psychiatry at the School of Medicine Trinity College Dublin Ireland
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- Gregor Kohls
- Child Neuropsychology Section Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy University Hospital RWTH Aachen Germany
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- Kerstin Konrad
- Child Neuropsychology Section Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy University Hospital RWTH Aachen Germany
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- Jonna Kuntsi
- Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- Luisa Lazaro
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Biomedical Network Research Center on Mental Health (CIBERSAM) Barcelona Spain
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- Sara Lera‐Miguel
- Department of Child and Adolescent Psychiatry and Psychology Institute of Neurosciencies Hospital Clinic Barcelona Spain
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- Klaus‐Peter Lesch
- Division of Molecular Psychiatry Center of Mental Health University of Würzburg Würzburg Germany
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- Mario R. Louza
- Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil
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- Astri J. Lundervold
- Department of Biomedicine K.G. Jebsen Centre for Neuropsychiatric Disorders University of Bergen Bergen Norway
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- Charles B Malpas
- Developmental Imaging Group Murdoch Children's Research Institute Melbourne Vic. Australia
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- Paulo Mattos
- D'Or Institute for Research and Education Rio de Janeiro Brazil
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- Hazel McCarthy
- Department of Psychiatry Trinity College Dublin Dublin Ireland
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- Leyla Namazova‐Baranova
- Research Institute of Pediatrics and Child Health of Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science and Higher Education of the Russian Federation Moscow Russia
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- Rosa Nicolau
- Department of Child and Adolescent Psychiatry and Psychology Institut of Neurosciencies Hospital Clinic Barcelona Spain
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- Joel T. Nigg
- Department of Behavioral Neuroscience Oregon Health & Science University Portland OR USA
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- Stephanie E. Novotny
- Olin Neuropsychiatry Research Center Hartford Hospital Hartford CT USA
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- Eileen Oberwelland Weiss
- Translational Neuroscience, Child and Adolescent Psychiatry University Hospital RWTH Aachen Aachen Germany
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- Ruth L. O'Gorman Tuura
- Center for MR Research University Children's Hospital Zurich Switzerland
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- Jaap Oosterlaan
- Clinical Neuropsychology Section Vrije Universiteit Amsterdam Amsterdam The Netherlands
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- Bob Oranje
- NICHE Lab Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands
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- Yannis Paloyelis
- Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience King’s College London London UK
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- Paul Pauli
- Department of Psychology (Biological Psychology Clinical Psychology and Psychotherapy) and Center of Mental Health University of Würzburg Würzburg Germany
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- Felipe A. Picon
- Adulthood ADHD Outpatient Program (ProDAH) Clinical Research Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
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- Kerstin J. Plessen
- Child and Adolescent Mental Health Centre Capital Region Copenhagen Copenhagen Denmark
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- J. Antoni Ramos‐Quiroga
- Department of Psychiatry Hospital Universitari Vall d’Hebron Barcelona Catalonia Spain
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- Andreas Reif
- Department of Psychiatry, Psychosomatic Medicine and Psychotherapy University Hospital Frankfurt Frankfurt Germany
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- Liesbeth Reneman
- Academic Medical Center Amsterdam University Medical Center Amsterdam The Netherlands
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- Pedro G.P. Rosa
- Laboratory of Psychiatric Neuroimaging (LIM‐21 Department and Institute of Psychiatry Hospital das Clinicas HCFMUSP Faculty of Medicine University of São Paulo Sao Paulo Sao Paulo Brazil
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- Katya Rubia
- Department of Child and Adolescent Psychiatry Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
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- Anouk Schrantee
- Department of Radiology and Nuclear Medicine Amsterdam University Medical Centers Amsterdam The Netherlands
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- Lizanne J.S. Schweren
- Department of Psychiatry Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE) University Medical Center Groningen University of Groningen Groningen The Netherlands
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- Jochen Seitz
- Child and Adolescent Psychiatry University Hospital RWTH Aachen Aachen Germany
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- Philip Shaw
- National Human Genome Research Institute and National Institute of Mental health Bethesda MD USA
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- Tim J. Silk
- School of Psychology Deakin University Geelong Vic. Australia
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- Norbert Skokauskas
- Centre for Child and Adolescent Mental Health NTNU Trondheim Norway
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- Juan C. Soliva Vila
- Department of Psychiatry and Forensic Medicine Universitat Autonoma de Barcelona Barcelona Spain
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- Michael C. Stevens
- Olin Neuropsychiatry Research Center Hartford Hospital Hartford CT USA
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- Gustavo Sudre
- National Human Genome Research Institute Bethesda MD USA
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- Leanne Tamm
- Department of Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati OH USA
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- Fernanda Tovar‐Moll
- D'Or Institute for Research and Education Rio de Janeiro Brazil
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- Theo G.M. van Erp
- Clinical Translational Neuroscience Laboratory Department of Psychiatry and Human Behavior University of California Irvine Irvine CA USA
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- Alasdair Vance
- Department of Paediatrics University of Melbourne Parkville Vic. Australia
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- Oscar Vilarroya
- Department of Psychiatry and Forensic Medicine Universitat Autonoma de Barcelona Barcelona Spain
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- Yolanda Vives‐Gilabert
- Instituto ITACA Universitat Politècnica de València València Spain
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- Georg G. von Polier
- Child and Adolescent Psychiatry University Hospital RWTH Aachen Aachen Germany
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- Susanne Walitza
- Department of Child and Adolescent Psychiatry and Psychotherapy Psychiatric Hospital University of Zurich Zurich Switzerland
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- Yuliya N. Yoncheva
- Department of Child and Adolescent Psychiatry NYU Child Study Center Hassenfeld Children’s Hospital at NYU Langone New York NY USA
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- Marcus V. Zanetti
- Department of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil
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- Georg C. Ziegler
- Division of Molecular Psychiatry Center of Mental Health University of Würzburg Würzburg Germany
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- David C. Glahn
- Olin Neuropsychiatry Research Center Hartford Hospital Hartford CT USA
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- Neda Jahanshad
- Imaging Genetics Center Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC Los Angeles CA USA
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- Sarah E. Medland
- Psychiatric Genetics QIMR Berghofer Medical Research Institute Brisbane Qld Australia
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- Paul M. Thompson
- Imaging Genetics Center Stevens Institute for Neuroimaging & Informatics Keck School of Medicine University of Southern California Los Angeles CA USA
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- Simon E. Fisher
- Language and Genetics Department Max Planck Institute for Psycholinguistics Nijmegen The Netherlands
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- Barbara Franke
- Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands
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- Clyde Francks
- Language and Genetics Department Max Planck Institute for Psycholinguistics Nijmegen The Netherlands
説明
<jats:sec><jats:title>Objective</jats:title><jats:p>Some studies have suggested alterations of structural brain asymmetry in attention‐deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left‐right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (<jats:italic>t</jats:italic> = 2.1, <jats:italic>p</jats:italic> = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (<jats:italic>t</jats:italic> = 2.7, <jats:italic>p</jats:italic> = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s <jats:italic>d</jats:italic> from −0.18 to 0.18) and would not survive study‐wide correction for multiple testing.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.</jats:p></jats:sec>
収録刊行物
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- Journal of Child Psychology and Psychiatry
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Journal of Child Psychology and Psychiatry 62 (10), 1202-1219, 2021-03-22
Wiley