IL-17 controls central nervous system autoimmunity through the intestinal microbiome
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- Tommy Regen
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Sandrine Isaac
- Department of Genomics and Health, Center for Advanced Research in Public Health, FISABIO, Valencia, Spain.
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- Ana Amorim
- Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
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- Nicolás Gonzalo Núñez
- Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
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- Judith Hauptmann
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Arthi Shanmugavadivu
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Matthias Klein
- Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Roman Sankowski
- Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
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- Ilgiz A. Mufazalov
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Nir Yogev
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Jula Huppert
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Florian Wanke
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Michael Witting
- Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, Munich, Germany.
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- Alexandra Grill
- Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Eric J. C. Gálvez
- Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.
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- Alexei Nikolaev
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Michaela Blanfeld
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Immo Prinz
- Institute of Immunology, Hannover Medical School, Hannover, Germany.
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- Philippe Schmitt-Kopplin
- Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, Munich, Germany.
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- Till Strowig
- Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.
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- Christoph Reinhardt
- Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Marco Prinz
- Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
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- Tobias Bopp
- Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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- Burkhard Becher
- Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
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- Carles Ubeda
- Department of Genomics and Health, Center for Advanced Research in Public Health, FISABIO, Valencia, Spain.
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- Ari Waisman
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
説明
<jats:p>IL-17 is a key safeguard of intestinal homeostasis, indirectly modulating the autoimmune response against CNS antigens.</jats:p>
収録刊行物
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- Science Immunology
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Science Immunology 6 (56), eaaz6563-, 2021-02-12
American Association for the Advancement of Science (AAAS)