Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
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- Alyssa N. Coyne
- Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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- Victoria Baskerville
- Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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- Benjamin L. Zaepfel
- Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
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- Frank Rigo
- Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.
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- Frank Bennett
- Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.
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- C. Patrick Lusk
- Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
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- Jeffrey D. Rothstein
- Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
書誌事項
- 公開日
- 2021-07-28
- DOI
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- 10.1126/scitranslmed.abe1923
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 13 (604), 2021-07-28
American Association for the Advancement of Science (AAAS)
