Population Analysis of Staphylococcus aureus Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia
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- Manouk Vrieling
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Stephen W. Tuffs
- Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
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- Gonzalo Yebra
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Marleen Y. van Smoorenburg
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Joana Alves
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Amy C. Pickering
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Joo Youn Park
- Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA
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- Nogi Park
- Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA
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- David E. Heinrichs
- Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
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- Lindert Benedictus
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Timothy Connelley
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Keun Seok Seo
- Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA
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- John K. McCormick
- Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
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- J. Ross Fitzgerald
- The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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- Steven J. Projan
- editor
説明
<jats:p> <jats:named-content content-type="genus-species">Staphylococcus aureus</jats:named-content> is an important human and animal pathogen associated with an array of diseases, including life-threatening necrotizing pneumonia and infective endocarditis. The success of <jats:named-content content-type="genus-species">S. aureus</jats:named-content> as a pathogen has been linked in part to its ability to manipulate the host immune response through the secretion of toxins and immune evasion molecules. The staphylococcal superantigens (SAgs) have been studied for decades, but their role in <jats:named-content content-type="genus-species">S. aureus</jats:named-content> pathogenesis is not well understood, and an appreciation for how SAgs manipulate the host immune response to promote infection may be crucial for the development of novel intervention strategies. Here, we characterized a widely prevalent, previously cryptic, staphylococcal SAg, SElW, that contributes to the severity of <jats:named-content content-type="genus-species">S. aureus</jats:named-content> infections caused by an important epidemic clone of <jats:named-content content-type="genus-species">S. aureus</jats:named-content> CC398. Our findings add to the understanding of staphylococcal SAg diversity and function and provide new insights into the capacity of <jats:named-content content-type="genus-species">S. aureus</jats:named-content> to cause disease. </jats:p>
収録刊行物
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- mBio
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mBio 11 (5), e02082-20-, 2020-10-27
American Society for Microbiology
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360017287073910016
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- ISSN
- 21507511
- 21612129
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- データソース種別
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- Crossref