Regional Gas Exchange and Cellular Metabolic Activity in Ventilator-induced Lung Injury
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- Guido Musch
- Assistant Professor of Anesthesia.
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- Jose G. Venegas
- Associate Professor of Anesthesia.
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- Giacomo Bellani
- Research Fellow, Department of Experimental and Environmental Medicine and Biotechnology, Ospedale San Gerardo and Università Milano-Bicocca, Monza, Italy.
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- Tilo Winkler
- Instructor in Anesthesia.
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- Tobias Schroeder
- Research Fellow, Department of Anesthesia and Critical Care.
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- Bodil Petersen
- Research Fellow, Department of Anesthesia and Critical Care.
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- R Scott Harris
- Assistant Professor of Medicine, Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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- Marcos F. Vidal Melo
- Assistant Professor of Anesthesia.
抄録
<jats:sec> <jats:title>Background</jats:title> <jats:p>Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell activation due to VILI was assessable by positron emission tomography and (2) whether cell activation due to dynamic overdistension alone was detectable when other manifestations of VILI were not yet evident.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The authors assessed cellular metabolic activity with [(18)F]fluorodeoxyglucose and regional gas exchange with [(13)N]nitrogen. In 12 sheep, the left ("test") lung was overdistended with end-inspiratory pressure of 50 cm H(2)O for 90 min, while end-expiratory derecruitment of this lung was either promoted with end-expiratory pressure of -10 cm H(2)O in 6 of these sheep (negative end-expiratory pressure [NEEP] group) or prevented with +10 cm H(2)O in the other 6 (positive end-expiratory pressure [PEEP] group) to isolate the effect of overdistension. The right ("control") lung was protected from VILI.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Aeration decreased and shunt fraction increased in the test lung of the NEEP group. [(18)F]fluorodeoxyglucose uptake of this lung was higher than that of the control lung and of the test lung of the PEEP group, and correlated with neutrophil count. When normalized by tissue fraction to account for increased aeration of the test lung in the PEEP group, [(18)F]fluorodeoxyglucose uptake was elevated also in this group, despite the fact that gas exchange had not yet deteriorated after 90 min of overdistension alone.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The authors could detect regional neutrophil activation in VILI even when end-expiratory derecruitment was prevented and impairment of gas exchange was not evident. Concomitant end-expiratory derecruitment converted this activation into profound inflammation with decreased aeration and regional shunting.</jats:p> </jats:sec>
収録刊行物
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- Anesthesiology
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Anesthesiology 106 (4), 723-735, 2007-04-01
Ovid Technologies (Wolters Kluwer Health)