The impact of type 2 diabetes on the development of tendinopathy

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  • Francesca Cannata
    Department of Endocrinology and Diabetes Campus Bio‐Medico University of Rome Rome Italy
  • Gianluca Vadalà
    Department of Orthopaedic and Trauma Surgery Campus Bio‐Medico University of Rome Rome Italy
  • Luca Ambrosio
    Department of Orthopaedic and Trauma Surgery Campus Bio‐Medico University of Rome Rome Italy
  • Nicola Napoli
    Department of Endocrinology and Diabetes Campus Bio‐Medico University of Rome Rome Italy
  • Rocco Papalia
    Department of Orthopaedic and Trauma Surgery Campus Bio‐Medico University of Rome Rome Italy
  • Vincenzo Denaro
    Department of Orthopaedic and Trauma Surgery Campus Bio‐Medico University of Rome Rome Italy
  • Paolo Pozzilli
    Department of Endocrinology and Diabetes Campus Bio‐Medico University of Rome Rome Italy

Abstract

<jats:title>Abstract</jats:title><jats:p>Tendinopathy is a chronic and often painful condition affecting both professional athletes and sedentary subjects. It is a multi‐etiological disorder caused by the interplay among overload, ageing, smoking, obesity (OB) and type 2 diabetes (T2D). Several studies have identified a strong association between tendinopathy and T2D, with increased risk of tendon pain, rupture and worse outcomes after tendon repair in patients with T2D. Moreover, consequent immobilization due to tendon disorder has a strong impact on diabetes management by reducing physical activity and worsening the quality of life. Multiple investigations have been performed to analyse the causal role of the individual metabolic factors occurring in T2D on the development of tendinopathy. Chronic hyperglycaemia, advanced glycation end‐products, OB and insulin resistance have been shown to contribute to the development of diabetic tendinopathy. This review aims to explore the relationship between tendinopathy and T2D, in order to define the contribution of metabolic factors involved in the degenerative process and to discuss possible strategies for the clinical management of diabetic tendinopathy.</jats:p>

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