Assessment of insertion/deletion polymorphism of the angiotensin-converting enzyme gene in abdominal aortic aneurysm and inguinal hernia

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  • George A Antoniou
    Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis;
  • Miltos K Lazarides
    Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis;
  • Stefania Patera
    Laboratory of Medical Biology, Democritus University of Thrace, 68100 Alexandroupolis, Greece
  • Stavros A Antoniou
    Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis;
  • Athanasios D Giannoukas
    Department of Vascular Surgery, University Hospital of Larissa, University of Thessaly Medical School, 41100 Larissa;
  • George S Georgiadis
    Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis;
  • Stavroula Vouliana Veletza
    Laboratory of Medical Biology, Democritus University of Thrace, 68100 Alexandroupolis, Greece

抄録

<jats:p> The aim of the paper is to determine whether the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is associated with abdominal aortic aneurysm (AAA) and inguinal hernia. A case-control study was conducted in 264 subjects: 65 patients with AAA, 91 patients with inguinal hernia, 19 patients with both AAA and hernia, and 89 controls were investigated for the ACE I/D polymorphism. Genotype analysis was performed using a polymerase chain reaction technique. Significant differences in the genotype between the patient groups and controls were identified (aneurysm versus control, P = 0.011; aneurysm plus hernia versus control, P = 0.022; hernia versus control, P = 0.001), whereas no differences were found within patient groups. Patients with AAA and/ or hernia had an increased prevalence of I/D heterozygosity, which persisted even after adjusting for differences in confounding clinical variables (aneurysm versus control, OR 0.3, 95% CI 0.2–0.8, P = 0.005; aneurysm plus hernia versus control, OR 0.3, 95% CI 0.1-0.9, P = 0.040; hernia versus control, OR 0.4, 95% CI 0.2–0.7, P = 0.004). In conclusion, an association between the heterozygote ACE I/D state and the presence of AAA and/or hernia was identified. The role of the ACE I/D polymorphism in aneurysm and hernia needs further investigation. </jats:p>

収録刊行物

  • Vascular

    Vascular 21 (1), 1-5, 2012-01-23

    SAGE Publications

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