Hair cells use active zones with different voltage dependence of Ca <sup>2+</sup> influx to decompose sounds into complementary neural codes
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- Tzu-Lun Ohn
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Mark A. Rutherford
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Zhizi Jing
- Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37073 Goettingen, Germany;
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- Sangyong Jung
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Carlos J. Duque-Afonso
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Gerhard Hoch
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Maria Magdalena Picher
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
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- Anja Scharinger
- Institute of Pharmacy, Department of Pharmacology and Toxicology, University of Innsbruck, A-6020 Innsbruck, Austria;
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- Nicola Strenzke
- Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37073 Goettingen, Germany;
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- Tobias Moser
- Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany;
抄録
<jats:title>Significance</jats:title> <jats:p> We hear sounds varying in intensity over six orders of magnitude using spiral ganglion neurons (SGNs), each of which changes its firing rates over only a fraction of this range. Somehow, the SGNs with different dynamic ranges collectively encode the full range of sound levels represented in the receptor potential of the inner hair cell (IHC) in the mammalian cochlea. Our study, combining subcellular imaging, mouse genetics, and auditory systems physiology, offers a unifying synaptic hypothesis for wide dynamic range sound encoding in the spiral ganglion. We propose that IHCs, from one receptor potential but via presynaptic active zones that vary in the voltage dependence of Ca <jats:sup>2+</jats:sup> influx, generate complementary codes on sound pressure level in functionally distinct SGNs. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (32), E4716-, 2016-07-26
Proceedings of the National Academy of Sciences