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- Francesca Luchetti
- Department of Biomolecular Sciences University of Urbino “Carlo Bo” Urbino Italy
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- Barbara Canonico
- Department of Earth, Life and Environmental Sciences University of Urbino “Carlo Bo” Urbino Italy
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- Desirée Bartolini
- Department of Pharmaceutical Sciences University of Perugia Perugia Italy
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- Marcella Arcangeletti
- Department of Biomolecular Sciences University of Urbino “Carlo Bo” Urbino Italy
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- Silvia Ciffolilli
- Department of Pharmaceutical Sciences University of Perugia Perugia Italy
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- Giuseppe Murdolo
- Department of Pharmaceutical Sciences University of Perugia Perugia Italy
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- Marta Piroddi
- Department of Pharmaceutical Sciences University of Perugia Perugia Italy
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- Stefano Papa
- Department of Biomolecular Sciences University of Urbino “Carlo Bo” Urbino Italy
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- Russel J. Reiter
- Department of Cellular and Structural Biology UT Health Science Center San Antonio TX USA
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- Francesco Galli
- Department of Pharmaceutical Sciences University of Perugia Perugia Italy
抄録
<jats:title>Abstract</jats:title><jats:p>Among the numerous functions of melatonin, the control of survival and differentiation of mesenchymal stem cells (<jats:styled-content style="fixed-case">MSCs</jats:styled-content>) has been recently proposed. MSCs are a heterogeneous population of multipotent elements resident in tissues such as bone marrow, muscle, and adipose tissue, which are primarily involved in developmental and regeneration processes, gaining thus increasing interest for tissue repair and restoration therapeutic protocols. Receptor‐dependent and receptor‐independent responses to melatonin are suggested to occur in these cells. These involve antioxidant or redox‐dependent functions of this indolamine as well as secondary effects resulting from autocrine and paracrine responses. Inflammatory cytokines and adipokines, proangiogenic/mitogenic stimuli, and other mediators that influence the differentiation processes may affect the survival and functional integrity of these mesenchymal precursor cells. In this scenario, melatonin seems to regulate signaling pathways that drive commitment and differentiation of <jats:styled-content style="fixed-case">MSC</jats:styled-content> into osteogenic, chondrogenic, adipogenic, or myogenic lineages. Common pathways suggested to be involved as master regulators of these processes are the Wnt/<jats:italic>β</jats:italic>‐catenin pathway, the <jats:styled-content style="fixed-case">MAPK</jats:styled-content>s and the, <jats:styled-content style="fixed-case">TGF</jats:styled-content>‐<jats:italic>β</jats:italic> signaling. In this respect melatonin emerges a novel and potential modulator of MSC lineage commitment and adipogenic differentiation. These and other aspects of the physiological and pharmacological effects of melatonin as regulator of <jats:styled-content style="fixed-case">MSC</jats:styled-content> are discussed in this review.</jats:p>
収録刊行物
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- Journal of Pineal Research
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Journal of Pineal Research 56 (4), 382-397, 2014-04-15
Wiley