Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes

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  • Lan Huang
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Fengyan Zhao
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Yi Qu
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Li Zhang
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Yan Wang
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Dezhi Mu
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China

説明

<jats:title>Abstract</jats:title> <jats:p>Hypoxic-ischemic encephalopathy (HIE), a serious disease leading to neonatal death, is becoming a key area of pediatric neurological research. Despite remarkable advances in the understanding of HIE, the explicit pathogenesis of HIE is unclear, and well-established treatments are absent. Animal models are usually considered as the first step in the exploration of the underlying disease and in evaluating promising therapeutic interventions. Various animal models of HIE have been developed with distinct characteristics, and it is important to choose an appropriate animal model according to the experimental objectives. Generally, small animal models may be more suitable for exploring the mechanisms of HIE, whereas large animal models are better for translational studies. This review focuses on the features of commonly used HIE animal models with respect to their modeling strategies, merits, and shortcomings, and associated neuropathological changes, providing a comprehensive reference for improving existing animal models and developing new animal models.</jats:p>

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