Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy
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- Youming Zhang
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Minli Qu
- Department of Endocrinology Xiangya Hospital, Central South University Changsha China
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- Xiaoping Yi
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Pei Zhuo
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Jingyi Tang
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Xin Chen
- Department of Endocrinology Xiangya Hospital, Central South University Changsha China
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- Gaofeng Zhou
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Ping Hu
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Ting Qiu
- Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu China
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- Wu Xing
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Yitao Mao
- Department of Radiology Xiangya Hospital, Central South University Changsha China
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- Bihong T Chen
- Department of Diagnostic Radiology City of Hope National Medical Center Duarte California
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- Jing Wu
- Department of Endocrinology Xiangya Hospital, Central South University Changsha China
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- Yuanchao Zhang
- Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu China
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- Weihua Liao
- Department of Radiology Xiangya Hospital, Central South University Changsha China
Description
<jats:title>Abstract</jats:title><jats:p>Although diabetic peripheral neuropathy (DPN) has long been considered a disease of the peripheral nervous system, recent neuroimaging studies have shown that alterations in the central nervous system may play a crucial role in its pathogenesis. Here, we used surface‐based morphometry (SBM) and tract‐based spatial statistics (TBSS) to investigate gray matter (GM) and white matter (WM) differences between patients with DPN (<jats:italic>n</jats:italic> = 67, 44 painless and 23 painful) and healthy controls (HCs; <jats:italic>n</jats:italic> = 88). Compared with HCs, patients with DPN exhibited GM abnormalities in the pre‐ and postcentral gyrus and in several deep GM nuclei (caudate, putamen, medial pallidum, thalamus, and ventral nuclear). They also exhibited altered WM tracts (corticospinal tract, spinothalamic tract, and thalamocortical projecting fibers). These findings suggest impaired motor and somatosensory pathways in DPN. Further, patients with DPN (particularly painful DPN) exhibited morphological differences in the cingulate, insula, prefrontal cortex, and thalamus, as well as impaired WM integrity in periaqueductal WM and internal and external capsules. This suggests pain‐perception/modulation pathways are altered in painful DPN. Intermodal correlation analyses found that the morphological indices of the brain regions identified by the SBM analysis were significantly correlated with the fractional anisotropy of brain regions identified by the TBSS analysis, suggesting that the GM and WM alterations were tightly coupled. Overall, our study showed sensorimotor and pain‐related GM and WM alterations in patients with DPN, which might be involved in the development of DPN.</jats:p>
Journal
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- Human Brain Mapping
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Human Brain Mapping 41 (3), 710-725, 2019-10-29
Wiley
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Details 詳細情報について
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- CRID
- 1360017290199794816
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- ISSN
- 10970193
- 10659471
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- Data Source
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- Crossref