Female reproductive dormancy in <i>Drosophila</i> is regulated by DH31-producing neurons projecting into the corpus allatum
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- Yoshitomo Kurogi
- , University of Tsukuba 1 Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan
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- Eisuke Imura
- , University of Tsukuba 2 Graduate School of Life and Environmental Sciences , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan
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- Yosuke Mizuno
- , University of Tsukuba 1 Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan
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- Ryo Hoshino
- , University of Tsukuba 1 Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan
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- Marcela Nouzova
- Florida International University 4 Department of Biological Sciences and BSI , , 11200 SW 8th street, Miami, FL 33199 , USA
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- Shigeru Matsuyama
- University of Tsukuba 6 Faculty of Life and Environmental Sciences , , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan
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- Akira Mizoguchi
- Aichi Gakuin University 7 Division of Liberal Arts and Sciences , , 12 Araike, Iwasaki-cho, Nisshin, Aichi 470-0195 , Japan
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- Shu Kondo
- Tokyo University of Science 8 Department of Biological Science and Technology, Faculty of Advanced Engineering , , Niijuku 6-3-1, Katsushika-ku, Tokyo 125-8585 , Japan
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- Hiromu Tanimoto
- , Tohoku University 10 Graduate School of Life Sciences , Katahira 2-1-1, Sendai, Miyagi 980-8577 , Japan
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- Fernando G. Noriega
- Florida International University 4 Department of Biological Sciences and BSI , , 11200 SW 8th street, Miami, FL 33199 , USA
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- Ryusuke Niwa
- , Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 3 Life Science Center for Survival Dynamics , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577 , Japan
書誌事項
- 公開日
- 2023-05-15
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0
- DOI
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- 10.1242/dev.201186
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis.</jats:p>
収録刊行物
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- Development
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Development 150 (10), dev201186-, 2023-05-15
The Company of Biologists