<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia
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- Grzegorz Sienski
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Priyanka Narayan
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Julia Maeve Bonner
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Nora Kory
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Sebastian Boland
- Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
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- Aleksandra A. Arczewska
- Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
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- William T. Ralvenius
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Leyla Akay
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Elana Lockshin
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Liang He
- Duke University, Durham, NC 27708, USA.
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- Blerta Milo
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Agnese Graziosi
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Valeriya Baru
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Caroline A. Lewis
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Manolis Kellis
- Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
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- David M. Sabatini
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
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- Li-Huei Tsai
- Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
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- Susan Lindquist
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
説明
<jats:p> <jats:italic>APOE4</jats:italic> -disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation. </jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 13 (583), 2021-03-03
American Association for the Advancement of Science (AAAS)
