Nutrition Regulates Innate Immunity in Health and Disease

DOI Web Site 1 Citations
  • Samuel Philip Nobs
    Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel;
  • Niv Zmora
    Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel;
  • Eran Elinav
    Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel;

Search this article

Description

<jats:p>Nutrient content and nutrient timing are considered key regulators of human health and a variety of diseases and involve complex interactions with the mucosal immune system. In particular, the innate immune system is emerging as an important signaling hub that modulates the response to nutritional signals, in part via signaling through the gut microbiota. In this review we elucidate emerging evidence that interactions between innate immunity and diet affect human metabolic health and disease, including cardiometabolic disorders, allergic diseases, autoimmune disorders, infections, and cancers. Furthermore, we discuss the potential modulatory effects of the gut microbiota on interactions between the immune system and nutrition in health and disease, namely how it relays nutritional signals to the innate immune system under specific physiological contexts. Finally, we identify key open questions and challenges to comprehensively understanding the intersection between nutrition and innate immunity and how potential nutritional, immune, and microbial therapeutics may be developed into promising future avenues of precision treatment.</jats:p>

Journal

Citations (1)*help

See more

Details 詳細情報について

Report a problem

Back to top